Shiying Shao a,b, Tiannan Guo b, Ruedi Aebersold b,c, a Division of Endocrinology, Tongji Hospital, Huazhong University of Science & Technology, Wuhan 430030, PR China b Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Wolfgang-Pauli-Str. 16, 8093, Switzerland c Faculty of Science, University of Zurich, 8057 Zurich, Switzerland Biochimica et Biophysica Acta 1854 (2015) 519-527