Proteotypic Features of NCI-60 Cancer Cells Obtained by SWATH-MS Predicts Phenotypes
One of the central hypotheses underlying the personalised/precision medicine and emerging omics fields dictates that specific molecular make-up of a cell or a tissue determines its (clinical) phenotypes. To date, mainly owing to the maturity and accessibility of DNA- and RNA- based techniques, forays into the molecular landscapes of diseases, in particular cancer, have primarily focused on the genomics, transcriptomics and epigenomics levels. Proteins drive and catalyse essentially all biochemical reactions in a cell. Conceivably, the proteotype – the precisely quantified acute state of the cellular proteome – represents more closely the physiological, phenotypical and mechanistic states of a cell at a given time compared to its DNA signatures or RNA transcripts (levels). Here we explored the link between the proteotype and phenotype.