Proteomic Dynamics of Colorectal Cancer Evolution Identifies Microenvironment Modulator PLOD2 as a Potential Novel Drug Target

Proteomic Dynamics of Colorectal Cancer Evolution Identifies Microenvironment Modulator PLOD2 as a Potential Novel Drug Target

Summary

• Proteomic dynamics of colorectal cancer evolution using PCTDIA.

• >6500 proteins quantified in 180 samples with high reproducibility (R2=0.931)

• 185 proteins involved in microenvironmental regulation contribute to colorectal cancer evolution.

• PLOD2 as a potential novel drug target for colorectal cancer patients with high expression of PLOD2.